What is Crestor?

Crestor, also known by its generic name rosuvastatin, is a drug administered orally and prescribed for lowering blood cholesterol levels in the body. Crestor always reduces the risk of strokes and heart diseases in people having diabetes and other risk factors such as coronary heart disease.

It hails from a class of drugs called statins, which also include Lipitor (atorvastatin),Mevacor(lovastatin), Zocor (simvastatin), Lescol (fluvastatin), and Pravachol (pravastatin). Like all other statins, Crestorinhibits the production of cholesterol in the liver.

Important Information

There are a few things that one needs to know about rosuvastatin in general, and Crestor in particular before starting a treatment plan for lowering cholesterol levels with the help of this drug.

People who are allergic to rosuvastatin should never take Crestor, branded or generic.

There are rare cases when Crestor can result in a condition that leads to a breakdown of the body’s skeletal muscles. Therefore, you need to report any unexplained muscle pain, tenderness, and weakness to your doctor immediately.

Avoid eating any foods rich in cholesterol or unsaturated fat. They limit the effect of Crestor in the body.

Like all other statins, Crestor also works best when taken as part of a complete program comprising of balanced diet, exercise and weight management apart from the medication.

Crestor can even pass on in the breast milk to the child. Hence, one should never breast feed while taking Crestor.

Crestorneeds to be stored at around room temperature, usually between 2-25º C (36-77º F).

What Should I Know Before Taking Crestor?

One needs to take a few precautions and be clear on all the aspects of Crestor before taking it. The following are the essential things one needs to know about Crestor in order to make the treatment absolutely safe and as side effect free as possible.

People with any history of liver disease or renal failure need to consult their doctor before taking Crestor.

If you take more than two alcoholic beverages every day, you should talk to your doctor about it before starting Crestor. The drug affects the liver and hence, people who drink are at an increased risk of forming complications

Consult with your doctor if you have a thyroid disorder of some kind.

People who are of Chinese descent have been known to develop complications and side effects from Crestor. Hence, they need to check with their doctor if it is ok for them to start taking Crestor.

Talk to your doctor if you are pregnant or are planning to be pregnant before taking Crestor. Crestor can harm the unborn child as well as the mother.


The main active ingredient in Lipitor is rosuvastatin. This is a HMG CoA reductase inhibitor, which works by blocking the enzyme responsible for producing cholesterol in the liver, thereby stopping cholesterol production and lowering its blood levels.

How it Works

Crestor belongs to a class of drugs known as HMG CoA reductase inhibitors, or statins. Statins basically reduce the levels of “bad” cholesterol i.e. low-density lipoprotein(LDL) as well as triglycerides, while increasing the blood levels of good high-density lipoprotein (HDL) cholesterol in the body. Crestor blocks the enzyme HMG-CoA reductase, thereby inhibiting the production of cholesterol in the liver.


Crestor tablets are available in 5, 10, 20, and 40 mg dosages. The starting dose is usually 5 mg daily and can be increased to 40 mg, depending on the patient’s response. Asian people absorb rosuvastatin much quicker and hence, they need to be given lower dosages. It is taken once daily, at any time of the day, both with and without food.


There are certain drugs that interact with Crestor and lead to harmful consequences for the patient. Hence, one needs to be clear about what other drugs should not be taken with Crestor in order to avoid doing any harm to oneself. Some of the most common drugs to be avoided while taking Crestor are

birth control pills;


blood thinnerslike warfarin


drugs containing niacin

any other statin

Side effects of Crestor(Rosuvastatin)

In case of any serious side effects from Crestor, one should stop taking the drug and contact the doctor at once. In fact, you should ideally get emergency medical help if you have any of these signs of an allergic reaction to Crestor:


swelling of the face, tongue, lips, or throat.

unexplained muscle pain

tenderness, weakness, etc.

unusual tiredness

dark colored urine

swelling and/or weight gain

less urination than normal

loss of appetite

clay-colored stools


Some less severe side effects of Crestor are as follows

depressed mood

mild muscle pain

sleep problems and nightmares

joint pain



mild nausea

Frequently Asked Questions

Q: Can Crestor be prescribed to children?

A:No, Crestor is not approved by the FDA for use in children younger than 10 years of age.

Q: Does Crestor help in anything apart from lowering cholesterol?

A: Even if you have a low cholesterol level, you can still benefit from Crestor, as it also cut the risk of heart disease by half in people with normal cholesterol levels but high levels of CRP protein.

Q: Are there Special Warnings with Crestor?

A: According to the FDA, Crestor can cause serious, but rare side effects that include muscle damage, liver and kidney damage.