Basic Information

Colospa / Colofac (Mebeverine Hydrochloride) is a ‘Musculotropic Antispasmodic Agent’ indicated for the treatment of irritable bowel syndrome and abdominal pain triggered as a result of intestinal muscle spasms. It is known for its therapeutic role in the treatment of intestinal ailments. The medication is available at market establishments under the brand names ‘Colofac’ and ‘Colospa’.

  • Irritable Bowel Disease

Irritable Bowel Disease or IBS is an illness characterized by constantly occurring abdominal pain or inflammation and fluctuating disturbances that occur during the excretion of faces from the body. The exact cause of pain and inflammation associated with IBS is still unknown. However, researchers believe the disease occurs when several genetic, non-genetic and environmental factors combine and act together with body’s immune system. The disease is not potential fatal and can be cured by lifestyle changes, diet and medications.

  • Abdominal Cramps or Intestinal Spasms              

Abdominal cramping, medically known as GI spasms is the occurrence of sporadic ache and discomfort in abdominal region. Notably, it is not a disease, but a condition that originates with other medical conditions such as wrong diet, infections, nausea, diarrhea, food poisoning, to name a few.
Colospa (Mebeverine HCL) relieves the symptoms of several abdominal disorders by dilating the smooth muscle tissues in the intestinal part and reducing the intensity of pain and spasticity without anti-cholinergic side effects. The medication ameliorates condition without disturbing the normal motility of the gut region.


Colospa / Colofac / Mebeverine drug must be consumed as directed by the physician. Follow your doctor’s advice closely. Every medication comes with a prescription manual that contains essential information about the drug. Read it carefully and adhere to all directions.

Do not increase or decrease your dosage on your own. Avoid overdose. Mebeverine works well when consumed at same time each day. In case you have any doubt, seek medical advice.

Colospa / Colofac / Mebeverine is an oral drug available in the form of tablets in dose strengths of 100 mg, 150 mg and 300 mg. Consult your doctor to know the right dosage and exact length of therapy. The usual dosage is thrice a day to be taken 20 minutes before meals. The medication is unfit for consumption in children less than 10 years of age. Use the medication for total prescribed duration and do not cease the usage suddenly as it may aggravate your health condition.

It may take several weeks for your condition to improve. Your doctor may alter your dosage when the symptoms get improved.


Mebeverine is not known to interact or influence the effects of other medications in order to develop any life-threatening situation. However, it is advised that a patient, before administering Colospa / Colofac / Mebeverine tablets, must tell a pharmacist about the medications he is using or has used earlier. This includes prescribed, over the counter, herbal drugs and health supplements. Share your medical history with your doctor so that he can ascertain the safety of the medication for you.


Colospa / Colofac / Mebeverine should not be consumed if you are hypersensitive towards the medication. Notify the details of any allergic condition you have suffered in the past to your doctor.
Patients suffering from any liver or kidney disorders, paralytic ileus, porphyria or any heart complications must administer this drug under strict medical supervision.

Pregnancy and Breastfeeding

Certain medications must be used with extreme care during pregnancy and lactation as it can be dangerously harmful to the fetus or infants. Mebeverine medication must be used with caution if you are pregnant. If you come to know about your pregnancy or have plans to attain pregnancy, inform your doctor right away before using this drug.
Colospa / Colofac / Mebeverine excretes into human breast milk, but the excreted amount is too low to cause any harm to the child. Seek medical advice on using Colospa / Mebeverine during lactation.

Side effects of Colospa / Colofac / Mebeverine

Like any other drug, Colospa / Colofac / Mebeverine too has its side effects. But it must be borne in mind that a drug is made available for public consumption after it goes through several medicinal trials to ascertain its safety and efficacy.  A drug is considered safe for use when the benefits outweigh risks.

Colospa / Colofac / Mebeverine side effects are appetite loss, dizziness, constipation, weakness, diarrhea, abdominal disturbances, sleeplessness or insomnia, hypersensitivity or allergies, angioedema, headache and low heart rate. In case a patient feels ill after taking Mebeverine tablets, he must strive for medical help immediately.