What is Nexium?

Nexium contains Esomeprazole which is a proton pump inhibitor. It acts by reducing the amount of acid produced in the stomach.

Nexium is used in the treatment of Gastro-oesophageal reflux disease in adults and children above 12 years of age. It is also used for treatment of ulcers in the stomach or upper part of the stomach

Nexium is used to treat the following conditions:

Gastro-oesophageal reflux disease – GERD occurs when the lower oesophageal sphincter (LES) opens spontaneously, for varying periods of time, or does not close properly and stomach contents i.e. digestive juices and acids, rise up with the food into the oesophagus.

Ulcers of the stomach or duodenum, the beginning of the small intestine. Ulcers occur when the gut is infected by bacteria named “Helicobacter pylori”. If you are suffering with this condition, your doctor may also prescribe some antibiotics to treat the infection and this will ultimately allow the ulcer to heal.

Stomach ulcers caused by consumption of NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).  Nexium is also used to prevent formation of stomach ulcers if you are continuously consuming NSAIDs.

Production of increased amount of gastrin hormone by the pancreas caused by tumorous growth in the pancreas or small intestines, which is also known as Zollinger-Ellison syndrome.

Before Consumption of Nexium

Do not start Nexium if:

You are allergic or hypersensitive to esomeprazole or any of the other ingredients of this medicine

You are allergic to other proton pump inhibitor medicines such as omeprazole, pantoprazole etc.

You are already taking nelfinavir (which is used for treatment of HIV).

Special Care with Nexium

Consult your doctor or talk to your pharmacist,

If you are suffering from severe hepatic problems.

If you are suffering from severe renal problems.

Nexium may conceal the symptoms of varied other diseases. Therefore, consult your doctor immediately if any of the below mentioned symptoms occur while taking Nexium:

If you lose weight unexpectedly or have problem while swallowing.

If you have problem of indigestion or stomach pain.

If you have blood streaks while vomiting or you start to vomit food.

If you have passed black stools (blood- present in faeces).

While taking Nexium if diarrhoea starts, call your doctor immediately as treatment with proton pump inhibitors lead to a slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter.

Taking other Medicines:

If you are consuming, or have recently consumed, any other medicines, please inform your doctor or pharmacist. This includes medicines that you have been prescribed or have bought without a prescription. This is because Nexium can affect the pharmacological response of some medicines or vice versa.
Inform your doctor or pharmacist if you are consuming any of the below mentioned medicines as your doctor may have to adjust your dosage or suggest another medicine to avoid any contradiction.

Atazanavir or nelfinavir which is used for the management of HIV.

Anti-Fungal drugs such as Ketoconazole, itraconazole or voriconazole.

Anti-depressant drugs such as Citalopram, imipramine or clomipramine for managing depression.

Diazepam, which is also used to treat anxiety, relax muscles or in some form of severe epilepsy such as status epileptus).

Anti epileptic drug like Phenytoin

Anticoagulant drugs such as warfarin which are used to thin your blood.

If you have problem of indigestion & heartburn and you are using Cisapride to control it.

Pregnancy and Breast-Feeding

Tell your doctor if you are pregnant or if you are planning to get pregnant. Your doctor will let you know whether to take Nexium or not.

If you are breast feeding, it is not advisable to take Nexium as it is not known whether esomperazole gets secreted in breast milk or not.

Taking Nexium with Food and Drink

Nexium can be taken at any time of the day, with or without food or can be taken on an empty stomach.

Driving and using Machines

Nexium does not affect your motor function so it will not affect your driving capabilities or to operate tools & machine.

How to Take Nexium:

Always follow the advice of your doctor while taking Nexium. If you are not sure about any abnormal symptom check it with your doctor or pharmacist.

Nexium is not recommended for children less than 12 years of age.

If you have taken this medicine continuously for more than 1 year, your doctor will monitor you to decide if you need to take the medicine furthur.

Nexium capsules have to be swallowed whole with water. These capsules should not be chewed or crushed. This is important as these capsules contain esomerazole pellets and these pellets have acid resistant coating to prevent the degradation of medicine by the acid which is present in your stomach.

If your doctor has adviced you to take the medicine when you need it, call your doctor immediately if you have some problem.


If you have consumed more capsules of Nexium than prescribed by your doctor, talk to your doctor or pharmacist immediately.

Missed Dose:

If you forget to take a dose, take it as soon as you remember it. However, if it is time for your next dose, skip the missed dose but do not in any case take two doses at the same time to make up for a forgotten dose.

Side Effects of Nexium (Esomeprazole)

Like all medicines, Nexium also causes certain side effects not all of which are manifested in an individual. The side effects can be classified as serious- which require you to stop taking drug immediately and rush to your doctor and other side effects may be a common occurrence which may or maynot need some dose adjustment.

Diarrohoea or constipation, stomach pain, flatulence


Nausea and Vomitting

Other rare side effects may include changes in blood count, disturbed sleep, tingling feeling in extremeties, sleeplessness, extreme weakness due to low sodium levels, vomiting and cramps, hives and vertigo.

This list is not exhaustive and it is recommended that you should consult your doctor in case of any changes that you observe.

Will Nexium cure GERD?

Nexium is used in the treatment of GERD. Nexium not only decreases continuous heartburn and other symptoms of acid reflux disease, it also cures the damage that acid reflux causes over time to the oesophagus.

What is in Nexium?

Nexium contains active ingredient Esomeprazole which is a proton pump inhibitor.

How does Nexium work?

Nexium is a proton pump inhibitor and works by inhibiting the action of the proton pumps present in the lining of the stomach, thus reducing the production of acid in the stomach.

Are there any drugs which cannot be taken in combination with Nexium?

Concomitant medication may need dose adjustment as the effect of the drug may be altered by the co-administered drug. Always inform your doctor of any medicine you may be taking which may or may not be a prescription medicine.

Nexium may affect the plasma levels of antiretroviral drugs like Atzanavir and Nelfinavir.

It is also advised to avoid taking Nexium with antifungals like Ketoconazole, itraconazole etc, iron salts, erlotinib, digoxin as gastric pH affects their bioavailability. This list is not inclusive and therefore you should inform your doctor of any medication you may be taking.

Can Nexium cause allergic reaction? If yes what are the signs of allergic reaction?

Very rarely Nexium can cause allergic reaction which is manifested as swelling in mouth or throat causing difficulty in swallowing or dizziness, wheezing, breathing irregularities etc. Immediately contact your healthcare provider if you get any such symptoms.

What happens if I miss a dose of Nexium?

If you miss a dose, take it as soon as you remember it. However, if it is time for your next dose, skip the missed dose but do not in any case take two doses at the same time to make up for a forgotten dose.